Clarissa Forneris

Graduate Student 2015-2019
After Mo Lab: Postdoctoral Fellow, ETH Zürich (with Prof. Jörn Piel)

Ph.D. Chemistry 2019
B.S. Chemistry, MIT
Mo Lab Publications
Forneris, C. C.*; Nguy, A. K. L.*; Seyedsayamdost, M. R. Mapping and Exploiting the Promiscuity of OxyB toward the Biocatalytic Production of Vancomycin Aglycone Variants. ACS Catal. 2020, 10, 9287-9298.
Ozturk, S.; Forneris, C. C.; Nguy, A. K. L.; Sorensen, E. J.; Seyedsayamdost, M. R. Modulating OxyB-Catalyzed Cross-Coupling Reactions in Vancomycin Biosynthesis by Incorporation of Diverse D-Tyr Analogs. J. Org. Chem. 2018, 83, 7309-7317.

Forneris, C. C.; Seyedsayamdost, M. R. In Vitro Reconstitution of OxyC Activity Enables Total Chemo-Enzymatic Syntheses of Vancomycin Aglycone Variants. Angew. Chem. Int. Ed. 2018, 57, 8084-8052.Forneris, C. C.*; Ozturk, S.*; Sorensen, E. J.; Seyedsayamdost, M. R. Installation of Multiple Aryl Ether Crosslinks onto Non-native Substrate Peptides by the Vancomycin OxyB. Tetrahedron, 2018, 74, 3231-3237.

Schramma, K. R.; Forneris, C. C.; Caruso, A.; Seyedsayamdost, M. R. Mechanistic Investigations of Lysine-Tryptophan Crosslink Formation Catalyzed by Streptococcal Radical SAM Enzymes. Biochemistry 2018, 57, 461-468.

Gibson, M. I.; Forneris, C. C.; Seyedsayamdost, M. R. Peptide Crosslinks Catalyzed by Metalloenzymes in Natural Products Biosynthesis. Invited Book Chapter Submission: “Cyclic Peptides” Edited by Jesko Koehnke, James Naismith, Wilfred A. van der Donk. RSC Press, pg. 141–163 (2017)

Forneris, C. C.; Ozturk, S.; Gibson, M. I.; Sorensen, E. J.; Seyedsayamdost, M. R. In Vitro Reconstitution of OxyA Enzymatic Activity Clarifies Late Steps in Vancomycin Biosynthesis. ACS Chem. Biol. 2017, 12, 2248-2253.

Nazari, B.; Forneris, C. C.; Gibson, M. I.; Moon, K.; Schramma, K. R.; Seyedsayamdost, M. R. Nonomuraea sp. ATCC 55076 Harbours the Largest Actinomycete Chromosome to Date and the Kistamicin Biosynthetic Gene Cluster. Med. Chem. Commun. 2017, 8, 780-788.

Princeton ACS Graduate Student Speaker Award (2018)
Eli Lilly-Edward C. Taylor Fellowship in Chemistry (2018)
WCC Merck Research Award (2018)