Alessio Caruso

Graduate Student 2017-2021
After Mo Lab: Postdoctoral Fellow, Harvard University (with Prof. Dan Kahne)

Ph.D. Chemistry 2021
B.S. Chemistry, Vassar College

Princeton Publications
Caruso, A.; Seyedsayamdost, M. R. Radical SAM Enzyme QmpB Installs Two 9-Membered Ring Macrocycles During Biogenesis of a Ribosomal Peptide Natural Product. J. Org. Chem. 2021, 86, 11284-11289.
Balo, A. R.; Caruso, A.; Tao, L.; Tantillo, D. J.; Seyedsayamdost, M. R.; Britt, R. D. Trapping a Cross-linked Lysine-Tryptophan Radical in the Catalytic Cycle of the Radical SAM Enzyme SuiB. Proc. Natl. Acad. Sci. USA 2021, 118, e2101571118

Seyedsayamdost, M. R.; Caruso, A.; Davis, K. M. The Chemistry and Structural Enzymology of RiPP-Modifying Radical SAM Metalloenzymes. “Comprehensive Natural Products III” Edited by Tadhg Begley and Ben Liu. Elsevier, pg. 49-64 (2020).

Caruso, A.*; Martinie, R. J.*; Bushin, L. B.; Seyedsayamdost, M. R. Macrocyclization via an Arginine-Tyrosine Crosslink Broadens the Reaction Scope of Radical SAM Enzymes. J. Am. Chem. Soc. 2019, 141, 16610-16614.

Caruso, A.; Bushin, L. B.; Clark, K. A.; Martinie, R. J.; Seyedsayamdost, M. R. A Radical Approach to Enzymatic β-Thioether Bond Formation. J. Am. Chem. Soc. 2019, 141, 990-997.

Schramma, K. R.; Forneris, C. F.; Caruso, A.; Seyedsayamdost, M. R.  Mechanistic Investigations of Lysine-Tryptophan Crosslink Formation Catalyzed by Streptococcal Radical SAM Enzymes. Biochemistry 2018, 57, 461-468.


Eli Lilly-Edward C. Taylor Fellowship in Chemistry (2020)

David V. Milligan ’62 Graduate Fellowship in Chemistry (2017)