Publications
Princeton Publications181. Kayrouz, C. M.; An, J. S.; Li, B. S. K., Seyedsayamdost, M. R., In Preparation. 180. Covington, B. C.; Dalvano, B. E.; Seyedsayamdost, M. R., In Preparation. 179. Stražar, M.; Mohamed, A.; Jeanfavre, S.; Invernizzi, R.; Mashin, E.; Avila-Pacheco, J.; Zimmerman, S.; Kadoki, M.; Lee, J.; Li, C.; Shin, Y.-H.; Shuai, M.; Pust, M.-M.; Ung, P.; Tan, Z. Y.; Pishchany, G.; Seyedsayamdost, M. R.; Graham, D. B.; Plichta, D.; Clish, C. B.; Xavier, R. J., In Revision. 178. Tigani, W.; Ganley, J. G.; Du, C.; Elsayed, S. S.; Diab, E.; Innocenti, P.; Rimboi, I.; Carrion-Bravo, V.; Martin, N. I.; Seyedsayamdost, M. R.; Raaijmakers, J. M.; van Wezel, G., In Revision. 177. Covington, B. C.; Dalvano, B. E.; Seyedsayamdost, M. R., In Revision. 176. Huang, Z. J.; Ying, V. Y.; Zheng, Z.; An, J. S.; Creasey, E. A.; Taylor, L. M.; Graham, D. B.; Xavier, R. J.; Seyedsayamdost, M. R., In Revision. 175. Dalvano, B. E.; Covington, B. C.; Seyedsayamdost, M. R. Discovery and Characterization of “Miranthins”, Trojan Horse Antibiotic Modulators of Bacterial Composition in the Oral Microbiome. Proc. Natl. Acad. Sci. U.S.A. 2026, 123, e2621138123. 174. Huang, J. Z.; Ying, V. Y.; Andersson, S. J.; Jeffrey, P. D.; Hammes-Schiffer, S.; Seyedsayamdost, M. R. A General Synthesis of Tryptophan-crosslinked Macrocyclic Peptides Enabled by a Dual-functional Directing Group. Nat. Synth. 2026, In Press. 173. Xiong, Z.; Ying, V. Y.; Huang, J. Z.; Kock, Z.; Clark, J. D.; Heeter, R. C.; An, J. S.; Matanachai, K.; Rodriques, S. G.; White, A. D.; Seyedsayamdost, M. R.; Zhong, E. D. Small Molecule Structure Elucidation from NMR Spectra with Generative and Reasoning Models. BioRxiv 2026, DOI: 172. Lee, Y. J.; Jang, E. S.; Hwang, H.-J.; Nam, Y.; Kim, T. G.; Hong, C.; Kim, E. L.; Seyedsayamdost, M. R.; Lee, S. R. Discovery of a Cryptic Secondary Metabolite, Plantazine, from the Mesophilic Plant Pathogen Burkholderia plantarii. Nat. Prod. Commun. 2026, 21, 1-11. 171. Gavriilidou, A.; Kubach, N.; Adamek, M.; Rodler, J.-P.; Kremer, S.; Huson, D. H.; Alduina, R.; Wright, G.; Seyemsayadost, M. R.; Wohlleben, W.; Donadio, S.; Sosio, M.; Xu, M.; Cryle, M. J.; Stegmann, E.; Ziemert, N. Structural and Evolutionary Analyses Support Reclassification of Glycopeptide Antibiotics as Xyclopeptides. BioRxiv 2026, DOI: 10.1101/2023.02.10.526856. 170. Nguy, A. K.; Ireland, K. A.; Kayrouz, C. M.; Caceres, J. C.; Huang, J. Z.; Ying, V. Y.; Quaye, J. A.; Greene, B. L.; Davis, K. M.; Seyedsayamdost, M. R. Discovery of Noncanonical Cytochrome P450 Enzymes in Nature. Nat. Chem. Biol. 2026, 22, 1693-1701. 169. Abbott, M. L.;Leeman, J. T.; Kayrouz, C. M.; Ireland, K. A.; Davis, K. M.; Seyedsayamdost, M. R. Widespread Biosynthesis of Histidine Dipeptides in Bacteria. J. Am. Chem. Soc. 2026, 148, 42939-42948. 168. Hu, L.; Jeong, M.; Seyedsayamdost, M. R., Sorensen, E. J. Homo-Clavulyne: Evaluation of a One-Atom Ring Expansion Strategy to Stabilize the Nine-Membered Ring Enediyne Biosynthetic Precursor. Synthesis 2026, In Press. DOI: 10.1055/a-2951-5568.
167. Lee, Y. J.; Hwang, H. J.; Lee, J.; Park, H. S.; Son, J.; Seyedsayamdost, M. R.; Bae, M.; Lee, S. R.; Kwon, Y. Natural Products with Atypical Atoms: Unveiling Structures, Biosynthetic Pathways, and Bioactivities. Nat. Prod. Rep. 2026, 43, 1817-1841.
166. An, J. S.; Overton, E. N.; Seyedsayamdost, M. R., Leveraging Antibiotic Hormesis for Cryptic Natural Product Discovery. Proc. Natl. Acad. Sci. U.S.A. 2026, 123, e2529841123. 165. Huang, J. Z.; Ying, V. Y.; Andersson, S. J.; Jeffrey, P. D.; Hammes-Schiffer, S.; Seyedsayamdost, M. R., A General Approach to Tryptophan-Crosslinked Macrocyclic Peptides Enabled by a Dual Functional Directing Group. ChemRxiv 2026, DOI: 10.26434/chemrxiv.15000326/v1.
164. Feng, X.; Li, X.; Zhang, Y.; Xu, J.; Xin, Z.; Yang, J.; Wu, M.; Zhang, S.; Yu, Z.; Qu, D.; He, T.; Wu, J.; Yu, J.; Liu, W.; Seyedsayamdost, M. R.; Wang, W.; Xu, F., Enhancing microbial metabolic capacity through high-energy electron beam-induced intense structural variations. Nat. Commun. 2026, 17, 2933. 163. Toraason, E.; Kaletsky, R.; Huang, J. Z.; Ying, V. Y.; Ye, X.; Longarini, E.; Weiner, A.; Ayyaz, W.; Ramirez-Garcia, P.; Muir, T. W.; Seyedsayamdost, M. R.; Murphy, C. T., Caenorhabditis elegans Avoids Todstoff, a Novel Nociceptive Necrotaxis Cue. BioRxiv 2026, DOI: 10.64898/2026.02.06.704436. 162. Um, S.; Jeong, H.; Ganley, J. G.; Covington, B. C.; Choi, S.; Zhang, C.; Kim, W.; Seyedsayamdost, M. R.; Moon, K., Cebulassopins, Antiproliferative Lasso Peptides from a Split Biosynthetic Operon. J. Am. Chem. Soc. 2026, 148, 6739-6743.
161. Shine, E. E.; Valastyan, J. S.; Ying, V. Y.; Huang, J. Z.; Seyedsayamdost, M. R.; Bassler, B. L.,Discovery of a Human Metabolite That Mimics the Bacterial Quorum-Sensing Autoinducer AI-2. J. Am. Chem. Soc. 2026, 148, 6258-6269.
160. Kim, J.; Park, S.-J.; Lee, Y. J.; Hwang, H.-J.; Kim, E. L.; Nam, Y..; Park, J.-D.; Seyedsayamdost, M. R.; Yun, H.; Lee, S. R., Algal-Bacterial Interaction-Driven Secondary Metabolites From Phaeobacter inhibens and Their Anti-Allergic Effects on Th2 Cell Immune Response. Arch. Pharm. 2026, 359, e70192.
159. Xiong, Z.; Zhang, Y.; Alauddin, F.; Cheng, C. X.; An, J. S.; Seyedsayamdost, M. R.; Zhong, E. D. Atomic Diffusion Models for Small Molecule Structure Elucidation from NMR Spectra. NeurIPS 2025, DOI: 10.48550/arXiv.2512.03127.
158. Han, E. J.; Ganley, J. G.; Winner, C. B.; Joon Soo An; Seyedsayamdost, M. R. Tetracycline Antibiotics Induce Biosynthesis of Pro-inflammatory Metabolites in the Immunobiotic Bacteroides dorei. ACS Cent. Sci. 2025, 11, 2421-2432. 157. Rued, B. E.; Dhariwal, A.; Covington, B. C.; Seyedsayamdost M.R.; Krivograd, S. A.; Pesavento, R. P.; Federle, M. J.; Petersen, F. C. Impact of the RaS-RiPP Tryglysin and Culturing Conditions on ex-vivo Oral Microbiomes. NPJ Biofilms Microbiomes 2025, 11, 152. 156. Park J.-D.; Lee, S. R.; Dhennezel, C.; Taylor, N.; Dame, A.; Kadoki, M.; Pishchany, G.; Graham, D. B.; Xavier, R. J.; Seyedsayamdost M. R. Elucidating the Role of Campylobacter concisus-derived Indole Metabolites in Gut Inflammation and Immune Modulation. Proc. Natl. Acad. Sci. USA 2025, 122, e2514071122. 155. Overton, E. N.; Zhang, Y.; Ngecu, W.; Seyedsayamdost, M. R. Chemical Synthetic Lethality Screens Identify Selective Drug Combinations against Pseudomonas aeruginosa. ACS Chem. Biol. 2025, 20, 1077-1086. 154. Humeidi R.; Oshiro-Rapley, N.; Gu, X.; An, J. S.; Ananthakrishnan, A. N.; Creasey, E. A.; Daly, M. J.; Schreiber, S. L.; Graham, D. B.; Seyedsayamdost, M. R.; Xavier, R. J. The Ulcerative Colitis-Associated Gene NXPE1 Catalyzes Glycan Modifications on Colonic Mucin. J. Am. Chem. Soc. 2025, 147, 10618-10628. 153. Zhang, C.; Li, Y.; Overton, E. N.; Seyedsayamdost, M. R., Peptide Surfactants with Post-translational C-Methylations that Promote Bacterial Development. Nat. Chem. Biol. 2025, 21, 1069-1075. 152. Ireland, K. A.; Kayrouz, C. M.; Abbott, M. L.; Seyedsayamdost, M. R.; Davis, K. M. Structural and Functional Analysis of SAM-Dependent N-Methyltransferases Involved in Ovoselenol and Ovothiol Biosynthesis. Structure 2025, 33, 528-538. 151. Covington, B. C.; Seyedsayamdost, M. R. Unlocking Hidden Treasures: The Evolution of High-Throughput Mass Spectrometry in Screening for Cryptic Natural Products. Nat. Prod. Rep. 2025, 42, In Press. DOI: 10.1039/d4np00026a 150. Ganley, J. G.; Seyedsayamdost, M. R. Iron Limitation Triggers Roseoceramide Biosynthesis and Membrane Remodeling in Marine Roseobacter. Proc. Natl. Acad. Sci. USA 2025, 122, e2414434122. 149. Huang, J. Z.; Ying, V. Y.; Seyedsayamdost, M. R. Synthesis of Non-canonical Tryptophan Variants via Rh-catalyzed C-H Functionalization of Anilines. Angew. Chem. Int. Ed. Engl. 2025, 64, e202414998. 148. Lee, S. R.; Gallant, É; Seyedsayamdost, M. R. Discovery of Cryptic Natural Products Using High-Throughput Elicitor Screening on Agar Media. Biochemistry 2025, 64, 20-25. 147. Ireland, K. A.; Kayrouz, C. M.; Abbott, M. L.; Seyedsayamdost, M. R.; Davis, K. M. Structural and Functional Analysis of SAM-Dependent N-Methyltransferases Involved in Ovoselenol and Ovothiol Biosynthesis. ChemRxiv 2024, DOI: 10.26434/chemrxiv-2024-do3h6. 146. Nguy, A. K.; Ireland, K. A.; Kayrouz, C. M.; Caceres, J. C.; Greene, B. L.; Davis, K. M.; Seyedsayamdost, M. R. Non-Canonical Cytochrome P450 Enzyme in Nature. BioRxiv 2024, DOI: 145. Humeidi, R.; Rapley, N.; Gu, X.; An, J. S.; Ananthakrishnan, A. N.; Creasey, E. A.; Daly, M. J.; Schreiber, S. L.; Graham, D. B.; Seyedsayamdost, M. R.; Xavier, R. J. The Ulcerative Colitis-Associated Gene NXPE1 Catalyzes Glycan Modification on Colonic Mucin. BioRxiv 2024, DOI: 144. Zhang, Y.; McWhorter, K. L.; Rosen, P. C.; Klaus, J. R.; Gallant, É.; Amaya Lopez, C. Y.; Jhunjhunwala, R.; Chandler, J. R.; Davis, K. M.; Seyedsayamdost, M. R. Combatting Melioidosis with Chemical Synthetic Lethality. Proc. Natl. Acad. Sci. USA 2024, 121, e2406771121. 143. Ireland, K. A.;* Kayrouz, C. M.;* Abbott, M. L.; Seyedsayamdost, M. R.; Davis, K. M. Structural Insights into the Convergent Evolution of Sulfoxide Synthase EgtB-IV, an Ergothioneine-biosynthetic Homolog of Ovothiol Synthase OvoA. Structure 2024, 32, 2013-2022.
142. Huang, J. Z.; Ying, V. Y.; Seyedsayamdost, M. R. Non-canonical Tryptophan Synthesis Enabled by Larock Umpolung. ChemRxiv 2024, DOI: 10.26434/chemrxiv-2024-7bgzg 141. Nguy, A. K. L.; Martinie, R. J.; Cai, A.; Seyedsayamdost, M. R. Detection of a Kinetically Competent Compound-I Intermediate in the Vancomycin Biosynthetic Enzyme OxyB. J. Am. Chem. Soc. 2024, 146, 19629-19634. 140. Kayrouz, C. M.;* Ireland, K. A.;* Ying, V.; Davis, K. M.; Seyedsayamdost, M. R. Discovery of the Selenium-containing Antioxidant Ovoselenol Derived from Convergent Evolution. Nat. Chem. 2024, 16, 1868-1875. 139. Kayrouz, C. M.; Seyedsayamdost, M. R. Enzymatic Strategies for Selenium Incorporation into Biological Molecules. Curr. Opin. Chem. Biol. 2024, 81, 102495. 138. Chioti, V. T.;* McWhorter, K. L.;* Blue, T. C.; Li, Y.; Xu, F.; Jeffrey, P. D.; Davis, K. M.; Seyedsayamdost, M. R. Nat. Chem. Biol. 2024, 20, 924-933. 137. Han E. J.; Seyedsayamdost, M. R. Genome Mining for New Enediyne Antibiotics. Curr. Opin. Chem. Biol. 2024, 81, 102481. 136. Han, E. J.; Jeong, M.; Lee, S. R.; Sorensen, E. J.; Seyedsayamdost, M. R. Hirocidins, Cytotoxic Metabolites from Streptomyces hiroshimensis, Induce Mitochondrion-mediated Apoptosis. Angew. Chem. Int. Ed. Engl. 2024, 63, e202405367.
135. Kayrouz, C. M.;* Ireland, K. A.;* Ying, V.; Davis, K. M.; Seyedsayamdost, M. R. Ovoselenol, a Selenium-containing Antioxidant Derived from Convergent Evolution. BioRxiv 2024, DOI: . 134. Kayrouz, C. M.; Seyedsayamdost, M. R. Making Selenometabolites Nature’s Way. Nat. Synth. 2024, 3, 426-427. 133. Zhang, C.; Seyedsayamdost, M. R. Widespread Peptide Surfactants with Post-translational C-methylations Promote Bacterial Development. BioRxiv 2024, DOI: .
132. Chioti, V. T.; Clark, K. A.; Ganley, J. G.; Han, E. J.; Seyedsayamdost, M. R. N–Cα Bond Cleavage Catalyzed by a Multinuclear Iron Oxygenase from a Divergent Methanobactin-like RiPP Gene Cluster. J. Am. Chem. Soc. 2024, 146, 7313-7323.
131. Johnson, B. A.; Clark, K. A.; Bushin, L. B.; Spolar C. N.; Seyedsayamdost, M. R. Expanding the Landscape of Noncanonical Amino Acids in RiPP Biosynthesis. J. Am. Chem. Soc. 2024, 146, 3805-3815.
130. Nguy, A. K. L.; Martinie, R. J.; Cai, A.; Seyedsayamdost, M. R. Detection of a Kinetically Competent Compound-I Intermediate in the Vancomycin Biosynthetic Enzyme OxyB. ChemRxiv 2023, DOI: 10.26434/chemrxiv-2023-28q5w. 129. Ireland, K. A.; Kayrouz, C. M.; Huang, J.; Seyedsayamdost, M. R.; and Davis, K. M. Structural Characterization and Ligand-Induced Conformational Changes of SenB, a Se-Glycosyltransferase Involved in Selenoneine Biosynthesis. Biochemistry 2023, 62, 3337-3342. 128. Chioti, V. T.; Clark, K. A.; Seyedsayamdost, M. R. N–Cα Bond Cleavage Catalyzed by a Multinuclear Iron Oxygenase from a Divergent Methanobactin-like RiPP Gene Cluster. ChemRxiv 2023, DOI: 10.26434/chemrxiv-2023-b3k7g. 127. Ireland, K. A.; Kayrouz C. M.; Huang, J.; Seyedsayamdost, M. R.; Davis K. M. Structural Characterization and Ligand-Induced Conformational Changes of SenB, a Se-Glycosyltransferase Involved in Selenoneine Biosynthesis. ChemRxiv 2023, DOI: 26434/chemrxiv-2023-r1pps. 126. Han, E. J.; Lee, S. R.; Townsend, C. A.; Seyedsayamdost M. R. Targeted Discovery of Cryptic Enediyne Natural Products via FRET-Coupled High-Throughput Elicitor Screening. ACS Chem. Biol. 2023, 18, 1854-1862. 125. Hauser, N.; Ireland, K. A.; Chioti, V. T.; Forneris, C. C.; Davis, K. M.; Seyedsayamdost, M. R. Robust Chemoenzymatic Synthesis of the Keratinimicin Aglycone Facilitated by the Structure and Reactivity of OxyB. ACS Chem. Biol. 2023, 1473-1479. 124. Han, E. J.; Lee, S. R.; Townsend C. A.; Seyedsayamdost, M. R. Targeted Discovery of Cryptic Enediyne Natural Products via FRET-coupled High-Throughput Elicitor Screening. ChemRxiv 2023, DOI: 10.26434/chemrxiv-2023-xg1g4. 123. Hauser, N.; Ireland, K. A.; Chioti, V. T.; Davis, K. M.; Seyedsayamdost, M. R. Robust Chemoenzymatic Synthesis of the Keratinimicin Aglycone Facilitated by the Structure and Reactivity of OxyB. ChemRxiv 2023, DOI: 10.26434/chemrxiv-2023-dklsp. 122. Seyedsayamdost, M. R.; Clardy J. Discovering Functional Small Molecules in the Gut Microbiome. Curr. Opin. Chem. Biol. 2023, 75, 102309.
120. Clark, K. A.; Covington, B. C.; Seyedsayamdost, M. R. Biosynthesis-Guided Discovery Reveals Enteropeptins as Alternative Sactipeptides Containing N-Methylornithine. Nat. Chem. 2022, 14, 1390-1398.
119. Clark, K. A.; Seyedsayamdost, M. R. Bioinformatic Atlas of Radical SAM Enzyme-Modified RiPP Natural Products Reveals an Isoleucine-Tryptophan Crosslink. J. Am. Chem. Soc. 2022, 144, 17876-17888. 118. Kayrouz, C. M.; Huang, J.; Hauser, N.; Seyedsayamdost, M. R. Biosynthesis of Selenium-Containing Small Molecules in Diverse Microorganisms. Nature 2022, 610, 199-204. 117. Covington, B. C.; Seyedsayamdost, M. R. Vitamin B3 Triggers Biosynthesis of Secondary Metabolite Dormancy Signals in Streptococcus suis. J. Am. Chem. Soc. 2022, 144, 14997-15001. 116. Li, Y.; Lee, S. R.; Han, E. J.; Seyedsayamdost, M. R. Momomycin, an Antiproliferative Cryptic Metabolite from the Oxytetracycline Producer Streptomyces rimosus. Angew. Chem. Int. Ed. 2022, 61, e202208573.
115. Bushin, L. B.; Covington, B. C.; Clark, K. A.; Caruso, A.; Seyedsayamdost, M. R. Bicyclostreptins are Radical SAM Enzyme-modified Peptides with Unique Cyclization Motifs. Nat. Chem. Biol. 2022, I18, 1135-1143.
114. Lee, S. R.; Seyedsayamdost, M. R. Induction of Diverse Cryptic Fungal Metabolites by Steroids and Channel Blockers. Angew. Chem. Int. Ed. 2022, 61, e202204519. 113. Seyedsayamdost, M. R.; Covington, B. C.; Zhang, Y.; Li, Y. Natural Product Discovery. Invited Book Chapter Submission: “Advanced Chemical Biology” Edited by Howard Hang, Jennifer Prescher, and Matthew Pratt. Wiley 2022, In Press. 112. Kayrouz, C. M.; Seyedsayamdost, M. R. A Novel and Prevalent Pathway in Microbial Selenium Metabolism. BioRxiv 2022, DOI: . 111. Zhang, Y.; Gallant, É.; Park, J.-D.; Seyedsayamdost, M. R. The Small Molecule Language of Dynamic Microbial Interactions. Annu. Rev. Microbiol. 2022, 76, 641-660. 110. Covington, B. C.; Seyedsayamdost, M. R. Guidelines for Metabolomics-guided Transposon Mutagenesis for Microbial Natural Product Discovery. Methods Enzymol. 2022, 665, 305-323.
109. Clark, K. A.; Bushin, L. B.; Seyedsayamdost, M. R. RaS-RiPPs in Streptococci and the Human Microbiome. ACS Bio. Med. Chem. Au 2022, 2, 328-339.
108. Horwitz, S. M.; Blue, T. C.; Ambarian, J. A.; Hoshino, S.; Seyedsayamdost, M. R., Davis, K. M. In Press. Structural Insights into Inhibition of the Drug Target Dihydroorotate Dehydrogenase by Bacterial Hydroxyalkylquinolines. RSC Chem. Biol. 2022, 3, 420-425.
107. Primdahl, K. G.; Kaupang, Å.; Park, J.-D.; Seyedsayamdost, M. R. ; Nolsøe, J. M. J.; Aursnes, M. On the Structure of Thailandene A: Synthetic Examination of the Cryptic Natural Product Aided by a Theoretical Approach. Synthesis 2022, 54, 1733-1744.
106. Park, J.-D.*; Li, Y.*; Moon, K.*; Han, E. J.; Lee, S. R.; Seyedsayamdost, M. R. Structural Elucidation of Cryptic Algaecides in Marine Algal-Bacterial Symbioses by NMR Spectroscopy and MicroED. Angew. Chem. Int. Ed. 2022, 61, e202114022.
105. Wang, R.; Gallant, É.; Wilson, M. Z.; Wu, Y.; Li, A.; Gitai, Z.; Seyedsayamdost, M. R. Algal p-Coumaric Acid Induces Oxidative Stress and Siderophore Biosynthesis in the Bacterial Symbiont Phaeobacter inhibens. Cell Chem. Biol. 2022, 29, 670-679.
104. Clark, K. A.; Covington, B. C.; Seyedsayamdost, M. R. Biosynthesis-guided Discovery of Enteropeptins, Unusual Sactipeptides Containing an N-Methylornithine. ChemRxiv 2021, DOI: 10.26434/chemrxiv-2021-jnv18.
103. Covington, B. C.; Seyedsayamdost, M. R. MetEx, a Metabolomics Explorer Application for Natural Product Discovery. ACS Chem. Biol. 2021, 16, 2825-2833. 102. Caruso, A.; Seyedsayamdost, M. R. Radical SAM Enzyme QmpB Installs Two 9-Membered Ring Macrocycles During Biogenesis of a Ribosomal Peptide Natural Product. J. Org. Chem. 2021, 86, 11284-11289. 101. Chioti, V. T.; McWhorter, K. L.; Xu, F.; Jeffrey, P. D.; Davis, K. M.; Seyedsayamdost, M. R. Structural and Functional Analysis of Keratinicyclin Reveals Synergistic Antibiosis with Vancomycin Against Clostridium difficile. ChemRxiv 2021, DOI: 10.26434/chemrxiv.14668545.v1. 100. Li, A.; Okada, B. K.; Rosen, P. C.; Seyedsayamdost, M. R. Piperacillin Triggers Virulence Factor Biosynthesis via the Oxidative Stress Response in Burkholderia thailandensis. Proc. Natl. Acad. Sci. USA 2021, 118, e2021483118. 99. Balo, A. R.; Caruso, A.; Tao, L.; Tantillo, D. J.; Seyedsayamdost, M. R.; Britt, R. D. Trapping a Cross-linked Lysine-Tryptophan Radical in the Catalytic Cycle of the Radical SAM Enzyme SuiB. Proc. Natl. Acad. Sci. USA 2021, 118, e2101571118.
98. Covington, B. C.; Xu, F.; Seyedsayamdost, M. R. A Natural Product Chemist’s Guide to Unlocking Silent Biosynthetic Gene Clusters. Annu. Rev. Biochem. 2021, 90, 763-788. 97. Rued, B. E.; Covington, B. C.; Bushin, L. B.; Szewczyk, G.; Laczkovich, I.; Seyedsayamdost, M. R.; Federle, M. J. Quorum Sensing in Streptococcus mutans Regulates Production of a Novel Class of Antimicrobial Compounds. mBio, 2021, 12, e02688-20.
96. Chen, Y.-C.; Seyedsayamdost, M. R.; Ringstad, N. A Microbial Metabolite Synergizes with Serotonin to Trigger C. elegans Reproductive Behavior. Proc. Natl. Acad. Sci. USA 2020, 117, 30589-30598. 95. Klaus, J. R.; Coulon, P. M. L.; Koirala, P.; Seyedsayamdost, M. R.; Déziel, E.; Chandler, J. R. Secondary Metabolites from the Burkholderia pseudomallei Complex: Structure, Ecology, and Evolution. J. Ind. Microbiol. Biotechnol. 2020, 47, 877-887. 94. Vrla, G. D.; Esposito, M.; Zhang, C.; Kang, Y.; Seyedsayamdost, M. R.; Gitai, Z. Cytotoxic Alkyl-quinolones Mediate Surface-induced Virulence in Pseudomonas aeruginosa. PLoS Pathog. 2020, 16, e1008867. 93. Bushin, L. B.; Covington, B. C.; Rued, B. E.; Federle, M. J.; Seyedsayamdost, M. R. Discovery and Biosynthesis of Streptosactin, a Sactipeptide with an Alternative Topology Encoded by Commensal Bacteria in the Human Microbiome. J. Am. Chem. Soc. 2020, 142, 16265-16275. 92. Yoshimura, A.; Covington, B. C.; Gallant, É.; Zhang, C.; Li, A.; Seyedsayamdost, M. R. Unlocking Cryptic Metabolites with Mass-Spectrometry-Guided Transposon Mutant Selection. ACS Chem. Biol. 2020, 15, 2766-2774. 91. Zhang, C. Seyedsayamdost, M. R. Discovery of a Cryptic Depsipeptide from Streptomyces ghanaensis via MALDI-MS-Guided High-Throughput Elicitor Screening. Angew. Chem. Int. Ed. 2020, 59, 23005-23009.
90. Forneris, C.C.*; Nguy, A. K. L.*; Seyedsayamdost, M. R. Mapping and Exploiting the Promiscuity of OxyB toward Biocatalytic Production of Vancomycin Aglycone Variants. ACS Catal. 2020, 10, 9287–9298.
89. Zhang, C.; Seyedsayamdost, M. R. CanE, an Iron/2-Oxoglutarate-Dependent Lasso Peptide Hydroxylase from Streptomyces canus. ACS Chem. Biol. 2020, 15, 890–894. 88. Seyedsayamdost, M. R.; Stallforth, P. Special Issue in Honor of Professor Jon Clardy. J. Nat. Prod. 2020, 83, 565–568. 87. Greenberg, E. P.; Chandler, J. R.; Seyedsayamdost, M. R. The Chemistry and Biology of Bactobolin: A 10-Year Collaboration with Natural Product Chemist Extraordinaire Jon Clardy. J. Nat. Prod. 2020, 83, 738–743.
86. Mao, D.*; Yoshimura, A.*; Wang, R.; Seyedsayamdost, M. R. Reporter-Guided Transposon Mutant Selection for Activation of Silent Biosynthetic Gene Clusters in Burkholderia thailandensis. ChemBioChem 2020, 21, 1826–1831.
85. Li, A.*; Mao, D.*; Yoshimura, A.*; Rosen, P. C.; Martin, W. L.; Gallant, É.; Wühr, M.; Seyedsayamdost, M. R. Multi-Omic Analyses Provide Links between Low-Dose Antibiotic Treatment and Induction of Secondary Metabolism in Burkholderia thailandensis. mBio 2020, 11, e03210-19. 84. Park, J.-D.*; Moon, K.*; Miller, C.; Rose, J.; Xu, F.; Ebmeier, C. C.; Jacobsen, J. R.; Mao, D.; Old, W. M.; DeShazer, D.; Seyedsayamdost, M. R. Thailandenes, Cryptic Polyene Natural Products Isolated from Burkholderia thailandensis Using Phenotype-Guided Transposon Mutagenesis. ACS Chem. Biol. 2020, 15, 1195–1203. 83. Gallant, É.; Li, A.; Davis, K. M.; Seyedsayamdost, M. R. Burkholderia-Derived Natural Products: From Discovery to Target Identification toward Chemical Ecology. Invited Book Chapter Submission: “Comprehensive Natural Products III” Edited by Tadhg Begley and Ben Liu. Elsevier, pg. 121–141 (2020). 82. Seyedsayamdost, M. R.; Caruso, A.; Davis, K. M. The Chemistry and Structural Enzymology of RiPP-Modifying Radical SAM Metalloenzymes. Invited Book Chapter Submission: “Comprehensive Natural Products III” Edited by Tadhg Begley and Ben Liu. Elsevier, pg. 49–64 (2020).
81. Isley, N. A.; Endo, Y.; Wu, Z. C.; Covington, B. C.; Bushin, L. B.; Seyedsayamdost, M. R.; Boger, D. L. Total Synthesis and Stereochemical Assignment of Streptide. J. Am. Chem. Soc. 2019, 141, 17361–17369.
80. Caruso, A.; Martinie, R. J.; Bushin, L. B.; Seyedsayamdost, M. R. Macrocyclization via an Arginine-Tyrosine Crosslink Broadens the Reaction Scope of Radical SAM Enzymes. J. Am. Chem. Soc. 2019, 141, 16610–16614.
79. Clark, K. A.; Bushin, L. B.; Seyedsayamdost, M. R. Aliphatic Ether Bond Formation Expands the Scope of Radical SAM Enzymes in Natural Product Biosynthesis. J. Am. Chem. Soc. 2019, 141, 10610–10615.
78. Okada, B. K.; Li, A.; Seyedsayamdost, M. R. Identification of the Hypertension Drug Guanfacine as an Anti-virulence Agent in Pseudomonas aeruginosa. ChemBioChem. 2019, 20, 2005–2011.
• Invited Submission for the “ChemBioTalents” Special Issue 77. Moon, K.; Xu, F.; Seyedsayamdost, M. R. Cebulantin, A Cryptic Lanthipeptide Antibiotic Uncovered via Bioactivity-Coupled HiTES. Angew. Chem. Int. Ed. 2019, 58, 5973–5977.
76. Moon, K.; Xu, F.; Zhang, C.; Seyedsayamdost, M. R. Bioactivity-HiTES Unveils Cryptic Antibiotics Encoded in Actinomycete Bacteria. ACS Chem. Biol. 2019, 14, 767–774.
75. Seyedsayamdost, M. R. Toward a Global Picture of Bacterial Secondary Metabolism. J. Ind. Microbiol. Biotechnol. 2019, 46, 301–311.
74. Stubbe, J.; Seyedsayamdost, M. R. Discovery of a New Class I Ribonucleotide Reductase with an Essential DOPA Radical and NO Metal as an Initiator of Long-Range Radical Transfer. Biochemistry 2019, 58, 435–437.
73. Xu, F.; Wu, Y.; Zhang, C.; Davis, K. M.; Moon, K.; Bushin, L. B.; Seyedsayamdost, M. R. A Genetics-Free Method for High-Throughput Discovery of Cryptic Microbial Metabolites. Nat. Chem. Biol. 2019, 15, 161–168.
72. Caruso, A.; Bushin, L. B.; Clark, K. A.; Martinie, R. J.; Seyedsayamdost, M. R. A Radical Approach to Enzymatic β-Thioether Bond Formation. J. Am. Chem. Soc. 2019, 141, 990–997. 71. Bushin, L. B.; Clark, K. A.; Pelczer, I.; Seyedsayamdost, M. R. Charting an Unexplored Streptococcal Biosynthetic Landscape Reveals a Unique Peptide Cyclization Motif. J. Am. Chem. Soc. 2018, 140, 17674–17684.
70. McRose, D. L.; Seyedsayamdost, M. R.; Morel F. M. M. Multiple Siderophores: Bug or Feature? J. Biol. Inorg. Chem. 2018, 23, 983-993.
69. Wu, Y.; Seyedsayamdost, M. R. The Polyene Natural Product Thailandamide A Inhibits Fatty Acid Biosynthesis in Gram-Positive and Gram-Negative Bacteria. Biochemistry 2018, 57, 4247-4251.
68. McRose, D. L.; Baars, O.; Seyedsayamdost, M. R.; Morel, F. M. M. Quorum Sensing and Iron Regulate a Two-for-One Siderophore Gene Cluster in Vibrio harveyi. Proc. Natl. Acad. Sci. USA. 2018, 115, 7581-7586. 67. Mao, D.*; Okada, B. K.*; Wu, Y.*; Xu, F.; Seyedsayamdost, M. R. Recent Advances in Activating Silent Biosynthetic Gene Clusters in Bacteria. Curr. Opin. Microbiol. 2018, 45, 156-163.
• Invited Submission for the “Antimicrobials” Special Issue edited by Profs. G. van Wezel & G. Wright. 66. Ozturk, S.; Forneris, C. C.; Nguy, A. K. L.; Sorensen, E. J.; Seyedsayamdost, M. R. Modulating OxyB-Catalyzed Cross-Coupling Reactions in Vancomycin Biosynthesis by Incorporation of Diverse D-Tyr Analogs. J. Org. Chem. 2018, 83, 7309-7317.
• Invited Submission for the “Synthesis of Antibiotics & Related Molecules” Special Issue edited by Profs. W. van der Donk, M. Movassaghi & K. Tatsuta. 65. Bushin, L. B.; Seyedsayamdost, M. R. Guidelines for Determining the Structures of Radical SAM Enzyme-Catalyzed Modifications in the Biosynthesis of RiPP Natural Products. Methods Enzymol. 2018, 606, 439–460.
• Invited Submission for the “Radical SAM Enzymes” Special Issue edited by Prof. V. Bandarian. 64. Klaus, J. R.; Deay, J.; Neuenswander, B.; Hursh, W.; Gao, Z.; Bouddhara, T.; Williams, T. D.; Douglas, J.; Monize, K.; Martins, P.; Majerczyk, C.; Seyedsayamdost, M. R.; Peterson, B. R.; Rivera, M.; Chandler, J. R. Malleilactone is a Burkholderia pseudomallei virulence factor regulated by antibiotics and quorum sensing. J. Bacteriol. 2018, 14, 1-15.
63. Forneris, C. C.; Seyedsayamdost, M. R. In Vitro Reconstitution of OxyC Activity Enables Total Chemo-Enzymatic Syntheses of Vancomycin Aglycone Variants. Angew. Chem. Int. Ed. 2018, 57, 8048-8052.
62. Forneris, C. C.*; Ozturk, S.*; Sorensen, E. J.; Seyedsayamdost, M. R. Installation of Multiple Aryl Ether Crosslinks onto Non-native Substrate Peptides by the Vancomycin OxyB. Tetrahedron 2018, 74, 3231-3237.
• Invited Submission for Prof. Herzon’s Tetrahedron Young Investigator Award Special Issue. 61. Gibson, M. I.; Seyedsayamdost, M. R. Small Biomolecules for Big Applications. ACS Cent. Sci. 2018, 4, 437-439.
60. Schramma, K. R.; Forneris, C. C.; Caruso, A.; Seyedsayamdost, M. R. Mechanistic Investigations of Lysine-Tryptophan Crosslink Formation Catalyzed by Streptococcal Radical SAM Enzymes. Biochemistry 2018, 57, 461-468.
59. Baars, O.; Zhang, X.; Gibson, M. I.; Stone, A. T.; Morel, F. M. M.; Seyedsayamdost, M. R. Crochelins, Siderophores with a Unprecedented Iron-Chelating Moiety from the Nitrogen-Fixing Bacterium Azotobacter chroococcum. Angew. Chem. Int. Ed. 2018, 57, 536-541. 58. Wu, Y.; Seyedsayamdost, M. R. Synergy and Target Promiscuity Drive Evolutionary Divergence in Bacterial Alkylquinolone Biosynthesis. Cell Chem. Biol. 2017, 24, 1437-1444. 57. Wang, R.; Seyedsayamdost, M. R. (2017) Roseochelin B, an Algaecidal Natural Product Synthesized by the Roseobacter Phaeobacter inhibens in Response to Algal Sinapic Acid. Org. Lett. 19, 5138-5141. 56. Gibson, M. I.; Forneris, C. C.; Seyedsayamdost, M. R. Peptide Crosslinks Catalyzed by Metalloenzymes in Natural Products Biosynthesis. Invited Book Chapter Submission: “Cyclic Peptides” Edited by Jesko Koehnke, James Naismith, Wilfred A. van der Donk. RSC Press, pg. 141–163 (2017). 55. Rosen, P. C.; Seyedsayamdost, M. R. Though Much is Taken, Much Abides: Finding New Antibiotics Using Old Ones. Biochemistry 2017, 56, 4925-4926. 54. Davis, K. M.; Schramma, K. R.; Hansen, W. A.; Bacik, J. P.; Khare, S. D.; Seyedsayamdost, M. R.; Ando, N. Structures of the Peptide-Modifying Radical SAM Enzyme SuiB Elucidate the Basis of Substrate Recognition. Proc. Natl. Acad. Sci. USA 2017, 114, 10420-10425.
53. Forneris, C. C.; Ozturk, S.; Gibson, M. I.; Sorensen, E. J.; Seyedsayamdost, M. R. In Vitro Reconstitution of OxyA Enzymatic Activity Clarifies Late Steps in Vancomycin Biosynthesis. ACS Chem. Biol. 2017, 12, 2248-2253.
52. Xu, F.; Nazari, B.*; Moon, K.*; Bushin, L. B.; Seyedsayamdost, M. R. Discovery of a Cryptic Antifungal Compound from Streptomyces albus J1074 Using High-Throughput Elicitor Screens. J. Am. Chem. Soc. 2017, 139, 9203-9212. 51. Reece, S.Y.; Seyedsayamdost, M. R. Long-Range Proton-Coupled Electron Transfer in the Escherichia coli Class 1a Ribonucleotide Reductase. Essays Biochem. 2017, 61, 281-292. 50. Mao, D.; Bushin, L. B.; Moon, K.; Wu, Y.; Seyedsayamdost, M. R. Discovery of scmR as a Global Regulator of Secondary Metabolism and Virulence in Burkholderia thailandensis E264. Proc. Natl. Acad. Sci. USA 2017, 114, E2920-E2928. 49. Schramma, K. R.; Seyedsayamdost, M. R. Lysine-Tryptophan-Crosslinked Peptides Produced by Radical SAM Enzymes in Pathogenic Streptococci. ACS Chem. Biol. 2017, 12, 922-927.
48. Wang, R.; Seyedsayamdost, M. R. Hijacking Exogenous Signals to Generate New Secondary Metabolites in Symbiotic Interactions. Nat. Rev. Chem. 2017, 1, 21. Highlighted on the Cover of Nature Reviews Chemistry, March Issue, 2017: 47. Nazari, B.; Forneris, C. C.; Gibson, M. I.; Moon, K.; Schramma, K. R.; Seyedsayamdost, M. R. Nonomuraea sp. ATCC 55076 Harbours the Largest Actinomycete Chromosome to Date and the Kistamicin Biosynthetic Gene Cluster. Med. Chem. Commun. 2017, 8, 780-788. • Invited Submission for “New Talent: Americas” Special Issue. 46. Papenfort, K.; Silpe, J. E.; Schramma, K. R.; Cong, J.-P.; Seyedsayamdost, M. R.; Bassler, B. L. A Vibrio cholerae Autoinducer-Receptor Pair that Controls Biofilm Formation. Nat. Chem. Biol. 2017, 13, 551-557. 45. Seyedsayamdost, M. R. Talking with Molecules: Marine Bacteria and Microalgae. Invited Book Chapter Submission: “The Chemistry of Microbimes” Edited by Tina Bahadori, Carole Bewley, Edward DeLong, Jim Fredrickson, Barabara Gerratana, David Rockcliffe. The National Academies Press, pg. 77–84 (2017). 44. Metelev, M.; Arseniev, A.; Bushin, L. B.; Kuznedelov, K.; Artamonova, T. O.; Kondratenko, R.; Khodorkovskii, M.; Seyedsayamdost, M. R.; Severinov, K. Acinetodin and Klebsidin, RNA Polymerase Targeting Lasso Peptides Produced by Human Isolates of Acinetobacter gyllenbergii and Klebsiella pneumoniae. ACS Chem. Biol. 2017, 12, 814-824. 43. Okada, B. K.; Seyedsayamdost, M. R. Antibiotic Dialogues: Induction of Silent Biosynthetic Gene Clusters by Exogenous Small Molecules. FEMS Microbiol. Rev. 2017, 41, 19–33. Highlighted in: 42. Okada, B. K.*; Wu, Y.*; Mao, D.; Bushin, L. B.; Seyedsayamdost, M. R. Mapping the Trimethoprim-Induced Secondary Metabolome of Burkholderia thailandensis. ACS Chem. Biol. 2016, 11, 2124–2130. 41. Wang, R.; Gallant, É.; Seyedsayamdost, M. R. Investigation of the Genetics and Biochemistry of Roseobacticide Production in the Roseobacter Clade Bacterium Phaeobacter inhibens. mBio 2016, 7, e02118.
40. Wilson, M. Z.; Wang, R.; Gitai, Z.; Seyedsayamdost, M. R. Mode of Action and Resistance Studies Unveil New Roles for Tropodithietic Acid as an Anticancer Agent and the γ-Glutamyl Cycle as a Proton Sink. Proc. Natl. Acad. Sci. USA 2016, 113, 1630-1635. Highlighted in: 39. Baars, O.; Zhang, X.; Morel, F. M.; Seyedsayamdost, M. R. The Siderophore Metabolome of Azotobacter vinelandii. Appl. Environ. Microbiol. 2015, 82, 27-39. 38. Truong, T. T.; Seyedsayamdost. M. R.; Greenberg, E. P.; Chandler, J. R. A Burkholderia thailandensis Acyl-Homoserine Lactone-Independent Orphan LuxR Homolog that Activates Production of the Cytotoxin Malleilactone. J. Bacteriol. 2015, 197, 3456-3462. 37. Schramma, K. R.*; Bushin, L. B.*; Seyedsayamdost, M. R. Structure and Biosynthesis of a Macrocyclic Peptide Containing an Unprecedented Lysine-to-Tryptophan Crosslink. Nature Chem. 2015, 7, 431-437.
36. Seyedsayamdost, M. R.*; Wang, R.; Kolter, R.; Clardy, J.* Hybrid Biosynthesis of Roseobacticides from Algal and Bacterial Precursor Molecules. J. Am. Chem. Soc. 2014, 136, 15150-15153. 35. Seyedsayamdost, M. R. High-Throughput Platform for the Discovery of Elicitors of Silent Bacterial Gene Clusters. Proc. Natl. Acad. Sci. USA 2014, 111, 7266-7271. Highlighted in: Prior Publications34. Seyedsayamdost, M. R.; Clardy J. Natural Products and Synthetic Biology. ACS Synth. Biol. 2014, 3, 745-747. 33. Wörsdörfer, B. A.; Conner, D. A.; Yokoyama, K.; Livada, J.; Seyedsayamdost, M. R.; Jiang, W.; Silakov, A.; Stubbe, J.; Bollinger, J. M. Jr.; Krebs, C. J. Function of the diiron cluster of the Escherichia coli class Ia ribonucleotide reductase in proton-coupled electron transfer. J. Am. Chem. Soc. 2013, 135, 8585-8593. 32. Chandler, J. R.; Truong, T. T.; Silva, P. M.; Seyedsayamdost, M. R.; Carr, G.; Radey, M.; Jacobs, M. A.; Sims, E. H.; Clardy, J.; Greenberg, E. P. Bactobolin resistance is conferred by mutations in the L2 ribosomal protein. MBio 2012, 3, e0049-e00512. 31. Seyedsayamdost, M. R.; Traxler, M. F.; Clardy, J.; Kolter, R. Old meets new: using interspecies interactions to detect secondary metabolite production in actinomycetes. Methods Enzymol. 2012, 517, 89-109. 30. Adler, C.; Corbalan, N. S.; Seyedsayamdost, M. R.; Pomares, M. F.; de Cristobal, R. E.; Clardy, J.; Kolter, R.; Vincent, P. A. Catecholate siderophores protect bacteria from pyochelin toxicity. PloS one 2012, 7, e46754-e46760. 29. Traxler, M. F.; Seyedsayamdost, M. R.; Clardy, J.; Kolter, R. Interspecies modulation of bacterial development through iron competition and siderophore piracy. Mol. Microbiol. 2012, 86, 628-644. 28. Seyedsayamdost, M. R.; Cleto, S.; Carr, G.; Vlamakis, H.; Vieira, M. J.; Kolter, R.; Clardy, J. Mixing and Matching Siderophore Clusters: Structure and Biosynthesis of Serratiochelins from Serratia sp. V4. J. Am. Chem. Soc. 2012, 134, 13550-13553. 27. Fernandes, N.; Case, R. J.; Longford, S. R.; Seyedsayamdost, M. R.; Steinberg, P. D.; Kjelleberg, S.; Thomas, T. Genomes and virulence factors of novel bacterial pathogens causing bleaching disease in the marine red alga Delisea pulchra. PloS one 2011, 6, e27387-e27398. 26. Seyedsayamdost, M. R.; Carr, G.; Kolter, R.; Clardy, J. Roseobacticides: Small Molecule Modulators of an Algal-Bacterial Symbiosis. J. Am. Chem. Soc. 2011, 133, 18343-18349. 25 Seyedsayamdost, M. R.; Traxler, M. F.; Zheng, S.-L.; Kolter, R.; Clardy, J. Structure and Biosynthesis of Amychelin, an Unusual Mixed-Ligand Siderophore from Amycolatopsis sp. AA4. J. Am. Chem. Soc. 2011, 133, 11434-11437. 24. Carr, G.; Seyedsayamdost, M. R.; Chandler, J. R.; Greenberg, E. P.; Clardy, J. Sources of Diversity in Bactobolin Biosynthesis by Burkholderia thailandensis E264. Org. Lett. 2011, 13, 3048-3051. 23. Seyedsayamdost, M. R.; Case, R. J.; Kolter, R.; Clardy, J. The Jekyll-and-Hyde chemistry of Phaeobacter gallaeciensis. Nature Chem. 2011, 3, 331-335. 22. Seyedsayamdost, M. R.; Yee, C. S.; Stubbe, J. Use of 2,3,5-F3Y-ß2 and 3-NH2Y-α2 to Study Proton-Coupled Electron Transfer in Escherichia coli Ribonucleotide Reductase. Biochemistry 2011, 50, 1403-1411. 21. Minnihan, E. C.; Seyedsayamdost, M. R.; Uhlin, U.; Stubbe, J. Kinetics of Radical Intermediate Formation and Deoxynucleotide Production in 3-Aminotyrosine-Substituted Escherichia coli Ribonucleotide Reductases. J. Am. Chem. Soc. 2011, 133, 9430-9440. 20. Seyedsayamdost, M. R.; Chandler, J. R.; Blodgett, J. A. V.; Lima, P. S.; Duerkop, B. A.; Oinuma, K.-I.; Greenberg, E. P.; Clardy, J., Quorum-Sensing-Regulated Bactobolin Production by Burkholderia thailandensis E264. Org. Lett. 2010, 12, 716-719. 19. Seyedsayamdost, M. R.; Stubbe, J. Replacement of Y730 and Y731 in the α2 Subunit of Escherichia coli Ribonucleotide Reductase with 3-Aminotyrosine Using an Evolved Suppressor tRNA/tRNA Synthetase Pair. Methods Enzymol. 2009; 462, 45-76. 18. Seyedsayamdost, M. R.; Argirevic, T.; Minnihan, E. C.; Stubbe, J.; Bennati, M. Structural Examination of the Transient 3-Aminotyrosyl Radical on the PCET Pathway of E. coli Ribonucleotide Reductase by Multifrequency EPR Spectroscopy. J. Am. Chem. Soc. 2009, 131, 15729-15738. 17. Reece, S. Y.; Lutterman, D. A.; Seyedsayamdost, M. R.; Stubbe, J.; Nocera, D. G. Re(bpy)(CO)(3)CN as a Probe of Conformational Flexibility in a Photochemical Ribonucleotide Reductase. Biochemistry 2009, 48, 5832-5838. 16. Offenbacher, A. R.; Vassiliev, I. R.; Seyedsayamdost, M. R.; Stubbe, J.; Barry, B. A. Redox-Linked Structural Changes in Ribonucleotide Reductase. J. Am. Chem. Soc. 2009, 131, 7496-7497. 15. Minnihan, E. C.; Seyedsayamdost, M. R.; Stubbe, J. Use of 3-Aminotyrosine To Examine the Pathway Dependence of Radical Propagation in Escherichia coli Ribonucleotide Reductase. Biochemistry 2009, 48, 12125-12132. 14. Seyedsayamdost, M. R.; Yee, C. S.; Stubbe, J. Site-specific incorporation of fluorotyrosines into the R2 subunit of E. coli ribonucleotide reductase by expressed protein ligation. Nat. Protoc. 2007, 2, 1225-1235. 13. Seyedsayamdost, M. R.; Chan, C. T. Y.; Mugnaini, V.; Stubbe, J.; Bennati, M. PELDOR spectroscopy with DOPA-beta 2 and NH2Y-alpha 2s: Distance measurements between residues involved in the radical propagation pathway of E-coli ribonucleotide reductase. J. Am. Chem. Soc. 2007, 129, 15748-15749. 12. Seyedsayamdost, M. R.; Xie, J.; Chan, C. T. Y.; Schultz, P. G.; Stubbe, J. Site-specific insertion of 3-aminotyrosine into subunit α2 of E. coli ribonucleotide reductase: Direct evidence for involvement of Y730 and Y731 in radical propagation. J. Am. Chem. Soc. 2007, 129, 15060-15071. 11. Reece, S. Y.; Seyedsayamdost, M. R.; Stubbe, J.; Nocera, D. G. Direct observation of a transient tyrosine radical competent for initiating turnover in a photochemical ribonucleotide reductase. J. Am. Chem. Soc. 2007, 129, 13828-13830. 10. Reece, S. Y.; Seyedsayamdost, M. R.; Stubbe, J.; Nocera, D. G. Photoactive peptides for light-initiated tyrosyl radical generation and transport into ribonucleotide reductase. J. Am. Chem. Soc. 2007, 129, 8500-8509. 9. Seyedsayamdost, M. R.; Stubbe, J. Forward and reverse electron transfer with the Y356DOPA-β2 heterodimer of E. coli ribonucleotide reductase. J. Am. Chem. Soc. 2007, 129, 2226-2227. 8. Reece, S. Y.; Seyedsayamdost, M. R.; Stubbe, J.; Nocera, D. G. Electron transfer reactions of fluorotyrosyl radicals. J. Am. Chem. Soc. 2006, 128, 13654-13655. 7. Seyedsayamdost, M. R.; Stubbe, J. Site-specific replacement of Y356 with 3,4-dihydroxyphenylalanine in the β2 subunit of E. coli ribonucleotide reductase. J. Am. Chem. Soc. 2006, 128, 2522-2523. 6. Seyedsayamdost, M. R.; Reece, S. Y.; Nocera, D. G.; Stubbe, J. Mono-, di-, tri-, and tetra-substituted fluorotyrosines: New probes for enzymes that use tyrosyl radicals in catalysis. J. Am. Chem. Soc. 2006, 128, 1569-1579. 5. Seyedsayamdost, M. R.; Yee, C. S.; Reece, S. Y.; Nocera, D. G.; Stubbe, J. pH rate profiles of FnY356-R2s (n=2, 3, 4) in Escherichia coli ribonucleotide reductase: Evidence that Y-356 is a redox-active amino acid along the radical propagation pathway. J. Am. Chem. Soc. 2006, 128, 1562-1568. 4. Guillen Schlippe, Y. V.; Riera, T. V.; Seyedsayamdost, M. R.; Hedstrom, L. Substitution of the conserved Arg-Tyr dyad selectively disrupts the hydrolysis phase of the IMP dehydrogenase reaction. Biochemistry 2004, 43, 4511-21. 3. Yee, C. S.; Seyedsayamdost, M. R.; Chang, M. C. Y.; Nocera, D. G.; Stubbe, J., Generation of the R2 subunit of ribonucleotide reductase by intein chemistry: Insertion of 3-nitrotyrosine at residue 356 as a probe of the radical initiation process. Biochemistry 2003, 42, 14541-14552. 2. Hedstrom, L.; Gan, L.; Schlippe, Y. G.; Riera, T.; Seyedsayamdost, M. IMP dehydrogenase: the dynamics of drug selectivity. Nucleic Acids Res. Supp. 2003, 3, 97-8. 1. Gan, L.; Seyedsayamdost, M. R.; Shuto, S.; Matsuda, A.; Petsko, G. A.; Hedstrom, L. The immunosuppressive agent mizoribine monophosphate forms a transition state analogue complex with inosine monophosphate dehydrogenase. Biochemistry 2003, 42, 857-863. |
121. Han, E. J.;* Lee, S. R.;* Hoshino, S.; Seyedsayamdost, M. R. Targeted Discovery of Cryptic Metabolites with Antiproliferative Activity. ACS Chem. Biol. 2022, 17, 3121-3130.
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